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Mouse Anti-UBTF Recombinant Antibody (6C6) (CBMAB-A9751-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
6C6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
UBTF (NP_055048, 551 a.a. ~ 650 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
upstream binding transcription factor, RNA polymerase I
Introduction
Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM
Entrez Gene ID
Human7343
Rat25574
UniProt ID
HumanP17480
RatP25977
Alternative Names
NOR-90; UBF
Function
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Biological Process
Biological Process positive regulation of transcription by RNA polymerase I Source:UniProtKB
Biological Process transcription by RNA polymerase I Source:UniProtKB1 Publication
Biological Process transcription initiation at RNA polymerase I promoter Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Nucleus, nucleolus
Involvement in disease
Neurodegeneration, childhood-onset, with brain atrophy (CONDBA):
An autosomal dominant neurodegenerative disease with onset in childhood, characterized by progressive cortical atrophy, developmental delay, developmental regression, loss of motor skills and ambulation, absence of language, and intellectual disability.
PTM
Phosphorylated and activated by PIK3CA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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