UBE2G2

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Ubiquitin Conjugating Enzyme E2 G2

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976).
Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569).

Biological Process cellular response to interferon-beta Source:UniProtKB1 Publication
Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication

Endoplasmic reticulum
Lipid droplet