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Rabbit Anti-UBE2G2 Recombinant Antibody (CBFYU-108) (CBMAB-U0108-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Clone
CBFYU-108
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 G2
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
Entrez Gene ID
Human7327
Mouse22213
Rat294331
Cattle614471
Monkey710862
Pig100624139
UniProt ID
HumanP60604
MouseP60605
RatB2RYD0
CattleQ17QG5
MonkeyF7HD05
PigI3LJ21
Alternative Names
UBC7
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976).
Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569).
Biological Process
Biological Process cellular response to interferon-beta Source:UniProtKB1 Publication
Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum
Lipid droplet
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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