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Rabbit Anti-UBE2G2 Recombinant Antibody (D8Z4G) (CBMAB-CP2922-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Clone
D8Z4G
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human UBE2G2 protein.
Specificity
Human, Mouse, Rat, Monkey, Cattle, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 G2
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Entrez Gene ID
Human7327
Mouse22213
Rat294331
Cattle614471
Monkey710862
Pig100624139
UniProt ID
HumanP60604
MouseP60605
RatB2RYD0
CattleQ17QG5
MonkeyF7HD05
PigI3LJ21
Alternative Names
Ubiquitin Conjugating Enzyme E2 G2; Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7); Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog; Yeast); E2 Ubiquitin-Conjugating Enzyme G2; Ubiquitin Carrier Protein G2; Ubiquitin-Protein Ligase G2; Ubiquitin-Conjugating Enzyme E2G 2;
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:20061386).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Involved in endoplasmic reticulum-associated degradation (ERAD) (PubMed:22607976).
Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation (PubMed:23223569).
Biological Process
Biological Process cellular response to interferon-beta Source:UniProtKB1 Publication
Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum
Lipid droplet
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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