TPO

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

Thyroid peroxidase

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Biological Process embryonic hemopoiesis Source:DFLAT1 Publication
Biological Process hormone biosynthetic process Source:UniProtKB-KW
Biological Process hydrogen peroxide catabolic process Source:UniProtKB-KW
Biological Process response to oxidative stress Source:InterPro
Biological Process thyroid hormone generation Source:Reactome

Membrane
Isoform 3
Cell surface

Thyroid dyshormonogenesis 2A (TDH2A):
A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

Extracellular: 19-846
Helical: 847-871
Cytoplasmic: 872-933

Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.