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Mouse Anti-Tpo Recombinant Antibody (CBYJT-4377) (CBMAB-T3870-YJ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYJT-4377
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 329-356 at the C-terminus of TPO of mouse origin
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 329-356

Target

Full Name
Thyroid peroxidase
Introduction
Tpo is a membrane-bound glycoprotein. Tpo plays a central role in thyroid gland function. Tpo functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in Tpo exhibit hypothyroid dwarfism and hearing impairment.
Entrez Gene ID
Human7173
Mouse22018
Rat54314
UniProt ID
HumanP07202
MouseP35419
RatP14650
Alternative Names
thyroid peroxidase; EC 1.11.1.8
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
Biological Process
Biological Process embryonic hemopoiesis Source:DFLAT1 Publication
Biological Process hormone biosynthetic process Source:UniProtKB-KW
Biological Process hydrogen peroxide catabolic process Source:UniProtKB-KW
Biological Process response to oxidative stress Source:InterPro
Biological Process thyroid hormone generation Source:Reactome
Cellular Location
Membrane
Isoform 3
Cell surface
Involvement in disease
Thyroid dyshormonogenesis 2A (TDH2A):
A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Topology
Extracellular: 19-846
Helical: 847-871
Cytoplasmic: 872-933
PTM
Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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