Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-TPO Recombinant Antibody (RM368) (CBMAB-BR475LY)


See all TPO antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human
Clone
RM368
Antibody Isotype
IgG
Application
IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
A peptide corresponding to the C-terminus of human TPO (Thyroid peroxidase)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 1% BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Thyroid peroxidase
Introduction
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Entrez Gene ID
7173
UniProt ID
P07202
Alternative Names
Thyroid peroxidase ;TPO;1.11.1.8 ;TPO ;
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
Biological Process
Biological Process embryonic hemopoiesis Source:DFLAT1 Publication
Biological Process hormone biosynthetic process Source:UniProtKB-KW
Biological Process hydrogen peroxide catabolic process Source:UniProtKB-KW
Biological Process response to oxidative stress Source:InterPro
Biological Process thyroid hormone generation Source:Reactome
Cellular Location
Membrane
Isoform 3
Cell surface
Involvement in disease
Thyroid dyshormonogenesis 2A (TDH2A):
A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Topology
Extracellular: 19-846
Helical: 847-871
Cytoplasmic: 872-933
PTM
Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-TPO Recombinant Antibody (RM368)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry