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TFPI

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

Full Name

TFPI Gene(Protein Coding) Tissue Factor Pathway Inhibitor

Function

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Biological Process

Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process cellular response to steroid hormone stimulusSource:UniProtKB1 Publication
Biological Process negative regulation of blood coagulationSource:UniProtKB1 Publication

Cellular Location

Isoform Alpha
Secreted
Isoform Beta
Microsome membrane

PTM

O-glycosylated.

Anti-TFPI antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-TFPI Recombinant Antibody (CB178A) (CBMAB-CA178LY)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CB178A

Application*: ELISA, IHC, IF

Recombinant Mouse Anti-TFPI Antibody (CBHb354) (CBMAB-Hb1012-LY)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb354

Application*: FC, Immuno assays, WB

Mouse Anti-TFPI (C-terminus) Recombinant Antibody (CBFYA-0249) (CBMAB-X0360-FY)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYA-0249

Application*: F, IA, WB

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2709) (CBMAB-T1898-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-2709

Application*: E, IP, WB

Rabbit Anti-TFPI Recombinant Antibody (CBYJT-2708) (CBMAB-T1897-YJ)

SDS

Target: TFPI

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-2708

Application*: WB, IP

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2707) (CBMAB-T1896-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2707

Application*: WB, IH

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2706) (CBMAB-T1895-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2706

Application*: WB, IH

Mouse Anti-TFPI Recombinant Antibody (5138) (CBMAB-T1894-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 5138

Application*: E, WB

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2705) (CBMAB-T1893-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-2705

Application*: WB, IH

Rabbit Anti-TFPI Recombinant Antibody (CBYJT-2704) (CBMAB-T1892-YJ)

SDS

Target: TFPI

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-2704

Application*: ED, P

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2703) (CBMAB-T1891-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2703

Application*: WB

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2702) (CBMAB-T1890-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-2702

Application*: WB, IH

Mouse Anti-TFPI Recombinant Antibody (CBYJT-2701) (CBMAB-T1889-YJ)

SDS

Target: TFPI

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-2701

Application*: E

TFPI Matched Antibody Pair (1199) (APMAB-1199LY)

SDS

Target: TFPI

Specificity: Human

Mouse Anti-Tfpi Recombinant Antibody (CBYJT-2716) (CBMAB-T1905-YJ)

SDS

Target: Tfpi

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Rat

Clone: CBYJT-2716

Application*: WB, IC, P, C, E, IP, IF, F

Rat Anti-Tfpi Recombinant Antibody (CBYJT-2715) (CBMAB-T1904-YJ)

SDS

Target: Tfpi

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJT-2715

Application*: E, WB

Rat Anti-Tfpi Recombinant Antibody (CBYJT-2714) (CBMAB-T1903-YJ)

SDS

Target: Tfpi

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJT-2714

Application*: WB

Rabbit Anti-Tfpi Recombinant Antibody (CBYJT-2712) (CBMAB-T1901-YJ)

SDS

Target: Tfpi

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-2712

Application*: E

Rabbit Anti-Tfpi Recombinant Antibody (CBYJT-2711) (CBMAB-T1900-YJ)

SDS

Target: Tfpi

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-2711

Application*: ED

Rabbit Anti-Tfpi Recombinant Antibody (CBYJT-2710) (CBMAB-T1899-YJ)

SDS

Target: Tfpi

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYJT-2710

Application*: EC

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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