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Mouse Anti-TFPI Recombinant Antibody (CBYJT-2709) (CBMAB-T1898-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2709
Antibody Isotype
IgG2a
Application
ELISA, IP, WB

Basic Information

Immunogen
NS0-derived rhTFPI
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 5% Trehalose, 40-50% Glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TFPI Gene(Protein Coding) Tissue Factor Pathway Inhibitor
Introduction
TFPI is a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Entrez Gene ID
7035
UniProt ID
P10646
Alternative Names
Tissue Factor Pathway Inhibitor; Extrinsic Pathway Inhibitor; Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor); TFPI1; LACI; EPI; Lipoprotein-Associated Coagulation Inhibitor; Anti-Convertin; TFI
Function
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Biological Process
Biological Process blood coagulationSource:ProtInc1 Publication
Biological Process cellular response to steroid hormone stimulusSource:UniProtKB1 Publication
Biological Process negative regulation of blood coagulationSource:UniProtKB1 Publication
Cellular Location
Isoform Alpha
Secreted
Isoform Beta
Microsome membrane
PTM
O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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