TDRD3

TDRD3 (Tudor Domain Containing 3) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is RMI1.

TDRD3 Gene(Protein Coding) Tudor Domain Containing 3

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process DNA topological changeIC:ComplexPortal

Cytoplasm
Nucleus
Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.