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Rabbit Anti-TDRD3 Recombinant Antibody (CBYJT-2466) (CBMAB-T1613-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Mouse, Rat
Clone
CBYJT-2466
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to human TDRD3 at C-terminal
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM HEPES, 150 mM NaCl, pH 7.5, 100 μg/mL BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
TDRD3 Gene(Protein Coding) Tudor Domain Containing 3
Introduction
TDRD3 (Tudor Domain Containing 3) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to TDRD3 include chromatin binding. An important paralog of TDRD3 is RMI1.
Entrez Gene ID
Human81550
Mouse219249
Rat306066
Monkey696228
UniProt ID
HumanQ9H7E2
MouseQ91W18
RatQ66HC1
MonkeyF7HF36
Alternative Names
Tudor Domain Containing 3
Function
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process DNA topological changeIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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