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Rabbit Anti-TDRD3 Recombinant Antibody (D3O2G) (CBMAB-CP2729-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D3O2G
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TDRD3 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TDRD3 Gene(Protein Coding) Tudor Domain Containing 3
Introduction
TDRD3 (Tudor Domain Containing 3) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is RMI1.
Entrez Gene ID
Human81550
Mouse219249
Rat306066
Monkey696228
UniProt ID
HumanQ9H7E2
MouseQ91W18
RatQ66HC1
MonkeyF7HF36
Alternative Names
Tudor Domain Containing 3;
Function
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process DNA topological changeIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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