TAX1BP1

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

TAX1BP1 Gene(Protein Coding) Tax1 Binding Protein 1

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processIBA:GO_Central1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activityISS:BHF-UCL

cytosol
extracellular exosome