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Rabbit Anti-TAX1BP1 Recombinant Antibody (D1D5) (CBMAB-CP2701-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
D1D5
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TAX1BP1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TAX1BP1 Gene(Protein Coding) Tax1 Binding Protein 1
Introduction
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Entrez Gene ID
8887
UniProt ID
Q86VP1
Alternative Names
Tax1 Binding Protein 1; Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1; TRAF6-Binding Protein; T6BP; Tax1-Binding Protein 1; CALCOCO3; TXBP151;
Function
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processIBA:GO_Central1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activityISS:BHF-UCL
Cellular Location
cytosol
extracellular exosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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