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Mouse Anti-TAX1BP1 Recombinant Antibody (3098C2a) (CBMAB-T1111-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3098C2a
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Immunogen
TAX1BP1 antibody was raised in mouse using recombinant Human Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1 (Tax1Bp1)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TAX1BP1 Gene(Protein Coding) Tax1 Binding Protein 1
Introduction
TAX1BP1 is a HTLV-1 tax1 binding protein. TAX1BP1 interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. TAX1BP1 may also have a role in the inhibition of inflammatory signaling pathways.
Entrez Gene ID
8887
UniProt ID
Q86VP1
Alternative Names
Tax1 Binding Protein 1; Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 1; TRAF6-Binding Protein; T6BP; Tax1-Binding Protein 1; CALCOCO3; TXBP151
Function
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processIBA:GO_Central1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activityISS:BHF-UCL
Cellular Location
cytosol
extracellular exosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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