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SPINT2

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
serine peptidase inhibitor, Kunitz type, 2
Function
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Biological Process
Biological Process basement membrane organizationIEA:Ensembl
Biological Process cellular response to BMP stimulusIEA:Ensembl
Biological Process epithelial cell morphogenesis involved in placental branchingIEA:Ensembl
Biological Process establishment or maintenance of cell polarityIEA:Ensembl
Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of neural precursor cell proliferationIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3):
A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.
Topology
Extracellular: 28-197
Helical: 198-218
Cytoplasmic: 219-252

Anti-SPINT2 antibodies

+ Filters
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Target: SPINT2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYH-3308
Application*: WB
Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2780
Application*: WB, EC
Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2781
Application*: WB
Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0045
Application*: E, F
Target: SPINT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0098
Application*: F
Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3763
Application*: E, WB
Target: SPINT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1161
Application*: E
Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2593
Application*: N, WB
Target: SPINT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2867
Application*: E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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