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Mouse Anti-SPINT2 (AA 28-197) Recombinant Antibody (CBFYH-2780) (CBMAB-H3847-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2780
Antibody Isotype
IgG1
Application
WB, ELISA(Cap)

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human HAI-2, aa 28-197
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 28-197

Target

Full Name
serine peptidase inhibitor, Kunitz type, 2
Introduction
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
10653
UniProt ID
O43291
Alternative Names
Serine Peptidase Inhibitor, Kunitz Type 2; Hepatocyte Growth Factor Activator Inhibitor Type 2; Serine Protease Inhibitor, Kunitz Type, 2; Placental Bikunin; HAI-2; HAI2
Function
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Biological Process
Biological Process basement membrane organizationIEA:Ensembl
Biological Process cellular response to BMP stimulusIEA:Ensembl
Biological Process epithelial cell morphogenesis involved in placental branchingIEA:Ensembl
Biological Process establishment or maintenance of cell polarityIEA:Ensembl
Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of neural precursor cell proliferationIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3):
A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.
Topology
Extracellular: 28-197
Helical: 198-218
Cytoplasmic: 219-252
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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