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Rabbit Anti-SPINT2 Recombinant Antibody (CBFYC-0098) (CBMAB-C0115-FY)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBFYC-0098
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant Mouse CD200 protein (50074-M08H)
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serine peptidase inhibitor, Kunitz type, 2
Introduction
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea.
Entrez Gene ID
20733
UniProt ID
Q9WU03
Alternative Names
HAI-2; C76321; AL024025
Function
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Biological Process
Biological Process basement membrane organizationIEA:Ensembl
Biological Process cellular response to BMP stimulusIEA:Ensembl
Biological Process epithelial cell morphogenesis involved in placental branchingIEA:Ensembl
Biological Process establishment or maintenance of cell polarityIEA:Ensembl
Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of neural precursor cell proliferationIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3):
A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.
Topology
Extracellular: 28-197
Helical: 198-218
Cytoplasmic: 219-252
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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