SLC6A4

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq]

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Biological Process brain morphogenesisISS:BHF-UCL
Biological Process cellular response to cGMPIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process circadian rhythmIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cerebellar granule cell precursor proliferationIEA:Ensembl
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of organ growthISS:BHF-UCL
Biological Process negative regulation of synaptic transmission, dopaminergicIEA:Ensembl
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process positive regulation of cell cycleIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of serotonin secretionIEA:Ensembl
Biological Process regulation of thalamus sizeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to estradiolIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to toxic substanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process social behaviorISS:BHF-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm ejaculationIEA:Ensembl
Biological Process vasoconstrictionIEA:Ensembl

Cell membrane
Endomembrane system
Endosome membrane
Synapse
Cell junction, focal adhesion
Could be part of recycling endosomes (PubMed:16870614).
Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity).
Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858).
Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).

Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation.