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Rabbit Anti-SLC6A4 Recombinant Antibody (BA0113) (CBMAB-0853CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0113
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human Serotonin transporter aa 50-150 (Cysteine residue)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Introduction
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Entrez Gene ID
Human6532
Mouse15567
Rat25553
UniProt ID
HumanP31645
MouseQ60857
RatP31652
Alternative Names
HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR
Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Biological Process
Biological Process brain morphogenesisISS:BHF-UCL
Biological Process cellular response to cGMPIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process circadian rhythmIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cerebellar granule cell precursor proliferationIEA:Ensembl
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of organ growthISS:BHF-UCL
Biological Process negative regulation of synaptic transmission, dopaminergicIEA:Ensembl
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process positive regulation of cell cycleIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of serotonin secretionIEA:Ensembl
Biological Process regulation of thalamus sizeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to estradiolIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to toxic substanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process social behaviorISS:BHF-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm ejaculationIEA:Ensembl
Biological Process vasoconstrictionIEA:Ensembl
Cellular Location
Cell membrane
Endomembrane system
Endosome membrane
Synapse
Cell junction, focal adhesion
Could be part of recycling endosomes (PubMed:16870614).
Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity).
Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858).
Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).
PTM
Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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