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Mouse Anti-SLC6A4 (AA 1-85) Recombinant Antibody (CBXS-0496) (CBMAB-S3445-CQ)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBXS-0496
Antibody Isotype
IgG1
Application
IHC-Fr

Basic Information

Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.6
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-85

Target

Full Name
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Introduction
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Entrez Gene ID
25553
UniProt ID
P31652
Alternative Names
SERT
Function
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Biological Process
Biological Process brain morphogenesisISS:BHF-UCL
Biological Process cellular response to cGMPIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process circadian rhythmIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cerebellar granule cell precursor proliferationIEA:Ensembl
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of organ growthISS:BHF-UCL
Biological Process negative regulation of synaptic transmission, dopaminergicIEA:Ensembl
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process positive regulation of cell cycleIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of serotonin secretionIEA:Ensembl
Biological Process regulation of thalamus sizeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to estradiolIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to toxic substanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process social behaviorISS:BHF-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm ejaculationIEA:Ensembl
Biological Process vasoconstrictionIEA:Ensembl
Cellular Location
Cell membrane
Endomembrane system
Endosome membrane
Synapse
Cell junction, focal adhesion
Could be part of recycling endosomes (PubMed:16870614).
Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity).
Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858).
Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).
PTM
Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation.
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For research use only. Not intended for any clinical use.

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