PDE4A

PDE4A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

PDE4A

Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Publications
Isoform 1
Efficiently hydrolyzes cAMP.
Isoform 2
Efficiently hydrolyzes cAMP.
Isoform 3
Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP.
Isoform 4
Efficiently hydrolyzes cAMP.
Isoform 6
Efficiently hydrolyzes cAMP.
Isoform 7
Efficiently hydrolyzes cAMP.

cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to xenobiotic stimulusIEA:Ensembl
G protein-coupled receptor signaling pathwayTAS:Reactome
Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Regulation of protein kinase A signalingIEA:Ensembl
Sensory perception of smellIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Isoform 1
Cytoplasm, perinuclear region
Isoform 2
Cytoplasm, perinuclear region
Cell projection, ruffle membrane
Isoform 3
Cytoplasm, cytosol
Isoform 4
Membrane ; Peripheral membrane protein
Isoform 4 has propensity for association with membranes.
Isoform 6
Cytoplasm, perinuclear region
Isoform 7
Cytoplasm, cytosol
Membrane ; Peripheral membrane protein
Predominantly cytosolic.

Isoform 1
Proteolytically cleaved by CASP3.
Isoform 2
Phosphorylated at Ser-119 by PKA.