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Mouse Anti-PDE4A Recombinant Antibody (4-34.10) (CBMAB-0192-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4-34.10
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Immunogen
Peptide: GDERSRETPESDRAN (aa. 617-635)
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PDE4A
Introduction
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. This protein hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Entrez Gene ID
Human5141
Rat25638
UniProt ID
HumanP27815
RatP54748
Alternative Names
PDE4; DPDE2; PDE46
Function
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Publications
Isoform 1
Efficiently hydrolyzes cAMP.
Isoform 2
Efficiently hydrolyzes cAMP.
Isoform 3
Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP.
Isoform 4
Efficiently hydrolyzes cAMP.
Isoform 6
Efficiently hydrolyzes cAMP.
Isoform 7
Efficiently hydrolyzes cAMP.
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to xenobiotic stimulusIEA:Ensembl
G protein-coupled receptor signaling pathwayTAS:Reactome
Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Regulation of protein kinase A signalingIEA:Ensembl
Sensory perception of smellIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Cytoplasm, perinuclear region
Isoform 2
Cytoplasm, perinuclear region
Cell projection, ruffle membrane
Isoform 3
Cytoplasm, cytosol
Isoform 4
Membrane ; Peripheral membrane protein
Isoform 4 has propensity for association with membranes.
Isoform 6
Cytoplasm, perinuclear region
Isoform 7
Cytoplasm, cytosol
Membrane ; Peripheral membrane protein
Predominantly cytosolic.
PTM
Isoform 1
Proteolytically cleaved by CASP3.
Isoform 2
Phosphorylated at Ser-119 by PKA.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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