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Mouse Anti-PDE4A Recombinant Antibody (3D4) (CBMAB-P1209-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3D4
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human PDE4A (NP_006193) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PDE4A
Introduction
PDE4A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
5141
UniProt ID
P27815
Alternative Names
Phosphodiesterase 4A; DPDE2; PDE46; Phosphodiesterase 4A, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E2); Phosphodiesterase E2 Dunce Homolog (Drosophila); Phosphodiesterase E2 Dunce Homolog, Drosophila; CAMP-Specific 3,5-Cyclic Phosphodiesterase 4A; Phosphodiesterase 4A, CAMP-Specific (Dunce;
Function
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Publications
Isoform 1
Efficiently hydrolyzes cAMP.
Isoform 2
Efficiently hydrolyzes cAMP.
Isoform 3
Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP.
Isoform 4
Efficiently hydrolyzes cAMP.
Isoform 6
Efficiently hydrolyzes cAMP.
Isoform 7
Efficiently hydrolyzes cAMP.
Biological Process
cAMP catabolic processIEA:UniProtKB-UniPathway
Cellular response to xenobiotic stimulusIEA:Ensembl
G protein-coupled receptor signaling pathwayTAS:Reactome
Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Regulation of protein kinase A signalingIEA:Ensembl
Sensory perception of smellIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Cytoplasm, perinuclear region
Isoform 2
Cytoplasm, perinuclear region
Cell projection, ruffle membrane
Isoform 3
Cytoplasm, cytosol
Isoform 4
Membrane ; Peripheral membrane protein
Isoform 4 has propensity for association with membranes.
Isoform 6
Cytoplasm, perinuclear region
Isoform 7
Cytoplasm, cytosol
Membrane ; Peripheral membrane protein
Predominantly cytosolic.
PTM
Isoform 1
Proteolytically cleaved by CASP3.
Isoform 2
Phosphorylated at Ser-119 by PKA.
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For research use only. Not intended for any clinical use.

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