NUTF2

This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

Nuclear Transport Factor 2

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

mRNA transportIEA:UniProtKB-KW
Nucleocytoplasmic transportManual Assertion Based On ExperimentIBA:GO_Central
Protein export from nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to nuclear poreISS:UniProtKB

Cytoplasm, cytosol
Nucleus outer membrane
Nucleus, nuclear pore complex
Nucleus inner membrane
Nucleus, nucleoplasm
At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.