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Mouse Anti-NUTF2 Recombinant Antibody (5A3) (CBMAB-N3709-WJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
5A3
Antibody Isotype
IgG2a
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Transport Factor 2
Introduction
NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Diseases associated with NUTF2 include Retinitis Pigmentosa 7. Among its related pathways are Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and Ran GTPase binding.
Entrez Gene ID
Human10204
Mouse68051
Rat291981
Monkey700488
UniProt ID
HumanP61970
MouseP61971
RatP61972
MonkeyH9EQR2
Alternative Names
NTF2; PP15; NTF-2
Function
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
Biological Process
mRNA transportIEA:UniProtKB-KW
Nucleocytoplasmic transportManual Assertion Based On ExperimentIBA:GO_Central
Protein export from nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to nuclear poreISS:UniProtKB
Cellular Location
Cytoplasm, cytosol
Nucleus outer membrane
Nucleus, nuclear pore complex
Nucleus inner membrane
Nucleus, nucleoplasm
At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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