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Mouse Anti-NUTF2 Recombinant Antibody (J.206.1) (CBMAB-N4049-WJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
J.206.1
Antibody Isotype
IgG2a
Application
ICC, IF, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.01M HEPES, 0.15M NaCl, 100μg/ml BSA, 50% glycerol, pH 7.5
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Transport Factor 2
Introduction
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
Entrez Gene ID
Human10204
Mouse68051
Rat291981
UniProt ID
HumanP61970
MouseP61971
RatP61972
Alternative Names
Nuclear Transport Factor 2; Placental Protein 15; NTF-2; NTF2; PP15;
Function
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.
Biological Process
mRNA transportIEA:UniProtKB-KW
Nucleocytoplasmic transportManual Assertion Based On ExperimentIBA:GO_Central
Protein export from nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Protein import into nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to nuclear poreISS:UniProtKB
Cellular Location
Cytoplasm, cytosol
Nucleus outer membrane
Nucleus, nuclear pore complex
Nucleus inner membrane
Nucleus, nucleoplasm
At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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