NEUROG3

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

Neurogenin 3

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).

Central nervous system development Source: ProtInc
Endocrine pancreas development Source: InterPro
Epithelial cell differentiation Source: Ensembl
Forebrain development Source: Ensembl
Hindbrain development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Nervous system development Source: ProtInc
Neuron differentiation Source: GO_Central
Peripheral nervous system development Source: ProtInc
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of dendrite morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spinal cord development Source: Ensembl
Transdifferentiation Source: UniProtKB

Nucleus

Diarrhea 4, malabsorptive, congenital (DIAR4):
A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.