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Mouse Anti-NEUROG3 Recombinant Antibody (CBWJN-0474) (CBMAB-N2101-WJ)


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Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse
Clone
CBWJN-0474
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Rat, Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurogenin 3
Introduction
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Entrez Gene ID
Human50674
Mouse11925
Rat60329
UniProt ID
HumanQ9Y4Z2
MouseP70661
RatO08718
Alternative Names
Neurogenin 3; Class A Basic Helix-Loop-Helix Protein 7; Protein Atonal Homolog 5; BHLHa7; Atoh5; NGN-3; Ngn3; Neurogenin-3; Math4B;
Function
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
Biological Process
Central nervous system development Source: ProtInc
Endocrine pancreas development Source: InterPro
Epithelial cell differentiation Source: Ensembl
Forebrain development Source: Ensembl
Hindbrain development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Nervous system development Source: ProtInc
Neuron differentiation Source: GO_Central
Peripheral nervous system development Source: ProtInc
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of dendrite morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spinal cord development Source: Ensembl
Transdifferentiation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Diarrhea 4, malabsorptive, congenital (DIAR4):
A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
More Infomation

Wejaphikul, K., Srilanchakon, K., Kamolvisit, W., Jantasuwan, S., Santawong, K., Tongkobpetch, S., ... & Shotelersuk, V. (2023). Novel Variants and Phenotypes in NEUROG3-Associated Syndrome. The Journal of Clinical Endocrinology & Metabolism, 108(1), 52-58.

Magenheim, J., Maestro, M. A., Sharon, N., Herrera, P. L., Murtaugh, L. C., Kopp, J., ... & Dor, Y. (2023). Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors. Cell Stem Cell, 30(4), 488-497.

Hou, Z., Liu, X., Jiang, W., Hou, Z., Yin, Y., Xie, C., ... & Yuan, Y. (2021). Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder. Behavioural Brain Research, 409, 113310.

Li, H. J., Ray, S. K., Kucukural, A., Gradwohl, G., & Leiter, A. B. (2021). Reduced Neurog3 gene dosage shifts enteroendocrine progenitor towards goblet cell lineage in the mouse intestine. Cellular and Molecular Gastroenterology and Hepatology, 11(2), 433-448.

Schreiber, V., Mercier, R., Jiménez, S., Ye, T., García-Sánchez, E., Klein, A., ... & Gradwohl, G. (2021). Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network. Molecular metabolism, 53, 101313.

Solorzano-Vargas, R. S., Bjerknes, M., Wang, J., Wu, S. V., Garcia-Careaga, M. G., Pitukcheewanont, P., ... & Martín, M. G. (2020). Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus. JCI insight, 5(1).

Ataíde Lima, R. P., Boico, V. F., Peruca, G. F., Cruz Rodrigues, K. C. D., Yariwake, V. Y., Neto, D. H., ... & de Oliveira Prada, P. (2019). Exposure to PM2. 5 during pregnancy or lactation increases methylation while reducing the expression of Pdx1 and NEUROG3 in mouse pancreatic islets. bioRxiv, 852509.

Liu, J., Banerjee, A., Herring, C. A., Attalla, J., Hu, R., Xu, Y., ... & Gu, G. (2019). Neurog3-independent methylation is the earliest detectable mark distinguishing pancreatic progenitor identity. Developmental cell, 48(1), 49-63.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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