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Mouse Anti-NEUROG3 Antibody (F25A1B3) (CBMAB-1453CQ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
F25A1B3
Antibody Isotype
IgG1, κ
Application
ChIP, IHC-P, IF, WB

Basic Information

Immunogen
Recombinant partial Ngn3; GST-Ngn3 fusion protein (aa 1-95)
Specificity
Mouse, Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-95

Target

Full Name
Neurogenin 3
Introduction
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Diseases associated with NEUROG3 include Diarrhea 4, Malabsorptive, Congenital and Diarrhea. Among its related pathways are Regulation of beta-cell development and Notch-mediated HES/HEY network.
Entrez Gene ID
Human50674
Mouse11925
UniProt ID
HumanQ9Y4Z2
MouseP70661
Alternative Names
ngn3; Atoh5; Math4B; bHLHa7
Function
Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
Biological Process
Central nervous system development Source: ProtInc
Endocrine pancreas development Source: InterPro
Epithelial cell differentiation Source: Ensembl
Forebrain development Source: Ensembl
Hindbrain development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Nervous system development Source: ProtInc
Neuron differentiation Source: GO_Central
Peripheral nervous system development Source: ProtInc
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of dendrite morphogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Spinal cord development Source: Ensembl
Transdifferentiation Source: UniProtKB
Cellular Location
Nucleus
Involvement in disease
Diarrhea 4, malabsorptive, congenital (DIAR4):
A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
More Infomation

Wejaphikul, K., Srilanchakon, K., Kamolvisit, W., Jantasuwan, S., Santawong, K., Tongkobpetch, S., ... & Shotelersuk, V. (2023). Novel Variants and Phenotypes in NEUROG3-Associated Syndrome. The Journal of Clinical Endocrinology & Metabolism, 108(1), 52-58.

Magenheim, J., Maestro, M. A., Sharon, N., Herrera, P. L., Murtaugh, L. C., Kopp, J., ... & Dor, Y. (2023). Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors. Cell Stem Cell, 30(4), 488-497.

Hou, Z., Liu, X., Jiang, W., Hou, Z., Yin, Y., Xie, C., ... & Yuan, Y. (2021). Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder. Behavioural Brain Research, 409, 113310.

Li, H. J., Ray, S. K., Kucukural, A., Gradwohl, G., & Leiter, A. B. (2021). Reduced Neurog3 gene dosage shifts enteroendocrine progenitor towards goblet cell lineage in the mouse intestine. Cellular and Molecular Gastroenterology and Hepatology, 11(2), 433-448.

Schreiber, V., Mercier, R., Jiménez, S., Ye, T., García-Sánchez, E., Klein, A., ... & Gradwohl, G. (2021). Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network. Molecular metabolism, 53, 101313.

Solorzano-Vargas, R. S., Bjerknes, M., Wang, J., Wu, S. V., Garcia-Careaga, M. G., Pitukcheewanont, P., ... & Martín, M. G. (2020). Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus. JCI insight, 5(1).

Ataíde Lima, R. P., Boico, V. F., Peruca, G. F., Cruz Rodrigues, K. C. D., Yariwake, V. Y., Neto, D. H., ... & de Oliveira Prada, P. (2019). Exposure to PM2. 5 during pregnancy or lactation increases methylation while reducing the expression of Pdx1 and NEUROG3 in mouse pancreatic islets. bioRxiv, 852509.

Liu, J., Banerjee, A., Herring, C. A., Attalla, J., Hu, R., Xu, Y., ... & Gu, G. (2019). Neurog3-independent methylation is the earliest detectable mark distinguishing pancreatic progenitor identity. Developmental cell, 48(1), 49-63.

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For research use only. Not intended for any clinical use.

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