HHEX

This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]

Hematopoietically Expressed Homeobox

Recognizes the DNA sequence 5'-ATTAA-3' (By similarity).

Transcriptional repressor (By similarity).

Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982).

Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).

May play a role in hematopoietic differentiation (PubMed:8096636).

Anterior/posterior pattern specification Source: UniProtKB
B cell differentiation Source: BHF-UCL
Cell differentiation Source: GO_Central
DNA conformation change Source: BHF-UCL
mRNA export from nucleus Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Poly(A)+ mRNA export from nucleus Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein localization to nucleus Source: BHF-UCL
Regulation of leukocyte proliferation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW

Nucleus