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Mouse Anti-HHEX Monoclonal Antibody (CBFYH-3062) (CBMAB-H1993-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3062
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hematopoietically Expressed Homeobox
Introduction
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
Entrez Gene ID
3087
UniProt ID
Q03014
Alternative Names
Hematopoietically Expressed Homeobox; Homeobox Protein HEX; Homeobox Protein PRH; PRHX; HEX; PRH
Function
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity).

Transcriptional repressor (By similarity).

Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982).

Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).

May play a role in hematopoietic differentiation (PubMed:8096636).
Biological Process
Anterior/posterior pattern specification Source: UniProtKB
B cell differentiation Source: BHF-UCL
Cell differentiation Source: GO_Central
DNA conformation change Source: BHF-UCL
mRNA export from nucleus Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by competitive promoter binding Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transcription by transcription factor localization Source: BHF-UCL
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
Poly(A)+ mRNA export from nucleus Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein localization to nucleus Source: BHF-UCL
Regulation of leukocyte proliferation Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Nucleus
More Infomation

Watanabe, H., Okada, H., Hirose, J., Omata, Y., Matsumoto, T., Matsumoto, M., ... & Tanaka, S. (2022). Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin‐Dependent Kinase Inhibitors. JBMR plus, 6(4), e10608.

González-Jiménez, A., López-Cotarelo, P., Agudo-Jiménez, T., Martínez-Ginés, M., García-Domínguez, J. M., Urcelay, E., & Espino-Paisán, L. (2022). Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis. International Journal of Molecular Sciences, 23(14), 7956.

Guo, Y., Zhu, Z., Huang, Z., Cui, L., Yu, W., Hong, W., ... & Liu, C. Y. (2022). CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Nature communications, 13(1), 4995.

Evseeva, M. N., Dyikanov, D. T., Karagyaur, M. N., Prikazchikova, T. A., Sheptulina, A. F., Balashova, M. S., ... & Kulebyakin, K. Y. (2021). Hematopoietically-expressed homeobox protein HHEX regulates adipogenesis in preadipocytes. Biochimie, 185, 68-77.

Starczynowski, D. T. (2020). HHEX expression drives AML development. Blood, The Journal of the American Society of Hematology, 136(14), 1575-1576.

Laidlaw, B. J., Duan, L., Xu, Y., Vazquez, S. E., & Cyster, J. G. (2020). The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nature immunology, 21(9), 1082-1093.

Galavi, H., Mollashahee‐Kohkan, F., Saravani, R., Sargazi, S., Noorzehi, N., & Shahraki, H. (2019). HHEX gene polymorphisms and type 2 diabetes mellitus: A case‐control report from Iran. Journal of cellular biochemistry, 120(10), 16445-16451.

Jang, S. W., Hwang, S. S., Kim, H. S., Kim, M. K., Lee, W. H., Hwang, S. U., ... & Lee, G. R. (2019). Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function. Proceedings of the National Academy of Sciences, 116(51), 25790-25799.

Lu, C. C., Chen, Y. T., Chen, S. Y., Hsu, Y. M., Lin, C. C., Tsao, J. W., ... & Tsai, F. J. (2018). Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg‑Ay/J mice and a Taiwanese Han Chinese population. Experimental and Therapeutic Medicine, 16(1), 185-191.

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For research use only. Not intended for any clinical use.

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