GRHL1

This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development.

GRHL1

Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642).

Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).

Isoform 1:
Functions as transcription activator.

Isoform 2:
May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.

Desmosome organization Source: Ensembl
Epidermis development Source: UniProtKB
Establishment of skin barrier Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of keratinocyte differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus