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Mouse Anti-GRHL1 Recombinant Antibody (CBLG1-3206) (CBMAB-G4845-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-3206
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GRHL1
Introduction
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
Entrez Gene ID
29841
UniProt ID
Q9NZI5
Alternative Names
Grainyhead Like Transcription Factor 1; Transcription Factor CP2-Like 2; Transcription Factor LBP-32; Mammalian Grainyhead; TFCP2L2; LBP32; NH32;
Function
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642).

Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).

Isoform 1:
Functions as transcription activator.

Isoform 2:
May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
Biological Process
Desmosome organization Source: Ensembl
Epidermis development Source: UniProtKB
Establishment of skin barrier Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of keratinocyte differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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