FGF21

Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]

Fibroblast Growth Factor 21

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc

Secreted