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Mouse Anti-FGF21 (AA 29-209) Recombinant Antibody (CBXF-2615) (CBMAB-F3042-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXF-2615
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human FGF-21, His29-Ser209
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 29-209

Target

Full Name
Fibroblast Growth Factor 21
Introduction
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue.
Entrez Gene ID
Human26291
Mouse56636
UniProt ID
HumanQ9NSA1
MouseQ9JJN1
Alternative Names
Fibroblast Growth Factor 21; FGF-21;
Research Area
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
More Infomation

Sommakia, S., Almaw, N. H., Lee, S. H., Ramadurai, D. K., Taleb, I., Kyriakopoulos, C. P., ... & Chaudhuri, D. (2022). FGF21 (Fibroblast Growth Factor 21) defines a potential cardiohepatic signaling circuit in end-stage heart failure. Circulation: Heart Failure, 15(3), e008910.

Lu, H., Jia, C., Wu, D., Jin, H., Lin, Z., Pan, J., ... & Wang, W. (2021). Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway. Cell death & disease, 12(10), 1-13.

Janzi, S., González-Padilla, E., Najafi, K., Ramne, S., Ahlqvist, E., Borné, Y., & Sonestedt, E. (2021). Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish Population. Nutrients, 13(11), 3954.

Wu, L., Qian, L., Zhang, L., Zhang, J., Zhou, J., Li, Y., ... & Jia, W. (2020). Fibroblast growth factor 21 is related to atherosclerosis independent of nonalcoholic fatty liver disease and predicts atherosclerotic cardiovascular events. Journal of the American Heart Association, 9(11), e015226.

Forsström, S., Jackson, C. B., Carroll, C. J., Kuronen, M., Pirinen, E., Pradhan, S., ... & Suomalainen, A. (2019). Fibroblast growth factor 21 drives dynamics of local and systemic stress responses in mitochondrial myopathy with mtDNA deletions. Cell metabolism, 30(6), 1040-1054.

Tucker, B., Li, H., Long, X., Rye, K. A., & Ong, K. L. (2019). Fibroblast growth factor 21 in non-alcoholic fatty liver disease. Metabolism, 101, 153994.

Martínez-Garza, Ú., Torres-Oteros, D., Yarritu-Gallego, A., Marrero, P. F., Haro, D., & Relat, J. (2019). Fibroblast growth factor 21 and the adaptive response to nutritional challenges. International journal of molecular sciences, 20(19), 4692.

Su, X., Kong, Y., & Peng, D. (2019). Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease. Clinica Chimica Acta, 498, 30-37.

Shi, Y., Wang, S., Peng, H., Lv, Y., Li, W., Cheng, S., & Liu, J. (2019). Fibroblast growth factor 21 attenuates vascular calcification by alleviating endoplasmic reticulum stress mediated apoptosis in rats. International journal of biological sciences, 15(1), 138.

Gao, R. Y., Hsu, B. G., Wu, D. A., Hou, J. S., & Chen, M. C. (2019). Serum fibroblast growth factor 21 levels are positively associated with metabolic syndrome in patients with type 2 diabetes. International journal of endocrinology, 2019.

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For research use only. Not intended for any clinical use.

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