FGF19

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

Fibroblast Growth Factor 19

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Animal organ morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central

Secreted