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Mouse Anti-FGF19 Monoclonal Antibody (Y36C) (CBMAB-1253-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
Y36C
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human FGF-19
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor 19
Introduction
FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 is a member of the fibroblast growth factor (FGF) family. Expression of FGF19 gene was detected only in fetal but not adult brain tissue.
Entrez Gene ID
9965
UniProt ID
O95750
Alternative Names
FGF19; Fibroblast growth factor 19; FGF-19
Research Area
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central
Cellular Location
Secreted
More Infomation

Chrysavgis, L., Giannakodimos, I., Chatzigeorgiou, A., Tziomalos, K., Papatheodoridis, G., & Cholongitas, E. (2022). The role of fibroblast growth factor 19 in the pathogenesis of nonalcoholic fatty liver disease. Expert Review of Gastroenterology & Hepatology, 16(9), 835-849.

Ursic-Bedoya, J., Chavey, C., Desandré, G., Meunier, L., Dupuy, A. M., Reyes, I. G. D., ... & Gregoire, D. (2022). Fibroblast growth factor 19 stimulates water intake. Molecular Metabolism, 60, 101483.

Liu, T., Tang, X., Cui, Y., Xiong, X., Xu, Y., Hu, S., ... & Wang, C. (2022). Fibroblast growth factor 19 improves LPS-induced lipid disorder and organ injury by regulating metabolomic characteristics in mice. Oxidative Medicine and Cellular Longevity, 2022.

Mohamed, G. A., Nashaat, E. H., Fawzy, H. M., & ElGhandour, A. M. (2022). Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma. World Journal of Hepatology, 14(3), 623.

Chen, H., Li, J., Zhang, D., Zhou, X., & Xie, J. (2021). Role of the fibroblast growth factor 19 in the skeletal system. Life Sciences, 265, 118804.

Chen, Z., Jiang, L., Liang, L., Koral, K., Zhang, Q., Zhao, L., ... & Tao, J. (2021). The role of fibroblast growth factor 19 in hepatocellular carcinoma. The American Journal of Pathology, 191(7), 1180-1192.

Zhou, Y., Yang, L., Bo, C., Zhang, X., Zhang, J., & Li, Y. (2021). MicroRNA-9-3p Aggravates Cerebral Ischemia/Reperfusion Injury by Targeting Fibroblast Growth Factor 19 (FGF19) to Inactivate GSK-3β/Nrf2/ARE Signaling. Neuropsychiatric Disease and Treatment, 17, 1989.

Guo, A., Li, K., & Xiao, Q. (2020). Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle. Biochemical and Biophysical Research Communications, 526(4), 1069-1076.

Maeda, T., Kanzaki, H., Chiba, T., Ao, J., Kanayama, K., Maruta, S., ... & Kato, N. (2019). Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma. BMC cancer, 19(1), 1-9.

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For research use only. Not intended for any clinical use.

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