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FASN

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Full Name
Fatty Acid Synthase
Research Area
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
Biological Process
Acetyl-CoA metabolic process Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Establishment of endothelial intestinal barrier Source: Ensembl
Ether lipid biosynthetic process Source: Ensembl
Fatty acid biosynthetic process Source: UniProtKB-UniPathway
Fatty acid metabolic process Source: ProtInc
Glandular epithelial cell development Source: Ensembl
Mammary gland development Source: Ensembl
Monocyte differentiation Source: Ensembl
Neutrophil differentiation Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Cellular Location
Cytoplasm; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PTM
S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.

Anti-FASN antibodies

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Mouse Anti-FASN Recombinant Antibody (CAP742) (CBMAB-AP2209LY)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP742
Application*: IF, IHC, IP, WB

Mouse Anti-FASN Recombinant Antibody (10H6) (CBMAB-0515-CN)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10H6
Application*: E, M

Mouse Anti-FASN Recombinant Antibody (S1) (CBMAB-A2854-LY)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: S1
Application*: SE, E

Mouse Anti-FASN Recombinant Antibody (3B3-1D6) (CBMAB-A2853-LY)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B3-1D6
Application*: WB, E

Mouse Anti-FASN Recombinant Antibody (2F9-B2-B6) (CBMAB-Z0334-LY)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: 2F9-B2-B6
Application*: WB, IP, IF

Mouse Anti-FASN (AA 1-439) Recombinant Antibody (CBXF-2868) (CBMAB-F3576-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2868
Application*: E, IF, WB

Mouse Anti-FASN Recombinant Antibody (CBXF-2867) (CBMAB-F3575-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2867
Application*: E, IF, IH, IP, WB

Mouse Anti-FASN (AA 2378-2477) Recombinant Antibody (CBXF-2866) (CBMAB-F3574-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2866
Application*: E

Mouse Anti-FASN Recombinant Antibody (CBXF-0345) (CBMAB-F3139-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0345
Application*: IF, E, WB

Mouse Anti-FASN Recombinant Antibody (CBXF-2575) (CBMAB-F3022-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXF-2575
Application*: WB

Mouse Anti-FASN Recombinant Antibody (CBXF-2574) (CBMAB-F3021-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2574
Application*: WB

Mouse Anti-FASN Recombinant Antibody (6B9) (CBMAB-F2790-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Hamster
Clone: 6B9
Application*: WB, IF, IP

Mouse Anti-FASN Recombinant Antibody (CBXF-3466) (CBMAB-F2786-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Hamster
Clone: CBXF-3466
Application*: WB, IF, IP

Mouse Anti-FASN Recombinant Antibody (CBXF-2148) (CBMAB-F2636-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXF-2148
Application*: P, WB

Mouse Anti-FASN (AA 942-973) Recombinant Antibody (CBXF-0339) (CBMAB-F2213-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXF-0339
Application*: IF, WB

Mouse Anti-FASN Recombinant Antibody (CBXF-0337) (CBMAB-F2211-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0337
Application*: IF, IH, IP, WB

Rabbit Anti-FASN Recombinant Antibody (CBXF-2057) (CBMAB-F2004-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: CBXF-2057
Application*: WB, IP, P, C, IF

Rabbit Anti-FASN Recombinant Antibody (CBXF-2225) (CBMAB-F2002-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Rat
Clone: CBXF-2225
Application*: IF, C, P, IP, WB

Rabbit Anti-FASN Recombinant Antibody (CBXF-1466) (CBMAB-F1927-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1466
Application*: F, IF, WB

Rabbit Anti-FASN Recombinant Antibody (CBXF-1476) (CBMAB-F1926-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1476
Application*: F, IF, WB

Mouse Anti-FASN Recombinant Antibody (CBXF-2014) (CBMAB-F1903-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2014
Application*: E, WB, P, IP

Mouse Anti-FASN Recombinant Antibody (CBXF-0344) (CBMAB-F1685-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXF-0344
Application*: WB

Mouse Anti-FASN Recombinant Antibody (CBXF-0343) (CBMAB-F1684-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0343
Application*: WB

Mouse Anti-FASN Recombinant Antibody (CBXF-0341) (CBMAB-F1683-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXF-0341
Application*: P, WB

Mouse Anti-FASN Recombinant Antibody (CBXF-0340) (CBMAB-F1681-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-0340
Application*: P, WB

Mouse Anti-FASN Recombinant Antibody (CBXF-2454) (CBMAB-F1587-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXF-2454
Application*: WB, IH, P

Mouse Anti-FASN Recombinant Antibody (CBXF-0334) (CBMAB-F1430-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-0334
Application*: WB, IC, P, C, E

Mouse Anti-FASN Recombinant Antibody (CBXF-0333) (CBMAB-F1429-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0333
Application*: WB, IC, P, C, E

Rabbit Anti-FASN Recombinant Antibody (CBXF-0336) (CBMAB-F1386-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: CBXF-0336
Application*: WB, IP, P, C, IF

Mouse Anti-FASN Recombinant Antibody (CBXF-2452) (CBMAB-F1341-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBXF-2452
Application*: WB

Mouse Anti-FASN Recombinant Antibody (497CT15.2.5) (CBMAB-F1198-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 497CT15.2.5
Application*: E, WB, IF

Mouse Anti-FASN Recombinant Antibody (CBXF-2453) (CBMAB-F1103-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-2453
Application*: WB, IH, P

Mouse Anti-FASN Recombinant Antibody (CBXF-1969) (CBMAB-F1100-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rabbit, Rat
Clone: CBXF-1969
Application*: WB, IF

Mouse Anti-FASN Recombinant Antibody (GT5210) (CBMAB-F1056-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: GT5210
Application*: WB

Mouse Anti-FASN Recombinant Antibody (CBXF-0342) (CBMAB-F0808-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0342
Application*: WB

Mouse Anti-FASN Recombinant Antibody (CBXF-0335) (CBMAB-F0670-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0335
Application*: WB, IH, IF, IP

Rabbit Anti-FASN Recombinant Antibody (CBXF-1248) (CBMAB-F0205-CQ)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1248
Application*: WB, IP, P, F, IF

Mouse Anti-FASN Recombinant Antibody (EG1182) (CBMAB-EN1422-LY)

Datasheet Datasheet SDS SDS
Target: FASN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG1182
Application*: ELISA, WB

FASN Matched Antibody Pair (412) (APMAB-412LY)

Datasheet Datasheet SDS SDS
Target: FASN
Specificity: Human
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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