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FASN Matched Antibody Pair (412) (APMAB-412LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-FASN polyclonal antibody, 100 ug
Detection Antibody
Anti-FASN Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Alternative Names
Fatty Acid Synthase; Short Chain Dehydrogenase/Reductase Family 27X, Member 1; FAS; EC 2.3.1.85; EC 6.3.3.1; EC 2.3.1; SDR27X1; OA-519;
Entrez Gene ID
2194
UniProt ID
P49327
More Infomation

Grunt, T. W., Lemberger, L., Colomer, R., López− Rodríguez, M. L., & Wagner, R. (2021). The pharmacological or genetic blockade of endogenous de novo fatty acid synthesis does not increase the uptake of exogenous lipids in ovarian cancer cells. Frontiers in oncology, 11, 610885.

Fhu, C. W., & Ali, A. (2020). Fatty acid synthase: an emerging target in cancer. Molecules, 25(17), 3935.

Che, L., Chi, W., Qiao, Y., Zhang, J., Song, X., Liu, Y., ... & Chen, L. (2020). Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut, 69(1), 177-186.

Zhang, N., Zhao, H., & Zhang, L. (2019). Fatty acid synthase promotes the palmitoylation of chikungunya virus nsP1. Journal of virology, 93(3), e01747-18.

Bruning, U., Morales-Rodriguez, F., Kalucka, J., Goveia, J., Taverna, F., Queiroz, K. C., ... & Carmeliet, P. (2018). Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation. Cell metabolism, 28(6), 866-880.

Jiang, L., Fang, X., Wang, H., Li, D., & Wang, X. (2018). Ovarian cancer-intrinsic fatty acid synthase prevents anti-tumor immunity by disrupting tumor-infiltrating dendritic cells. Frontiers in immunology, 9, 2927.

Zaytseva, Y. Y., Rychahou, P. G., Le, A. T., Scott, T. L., Flight, R. M., Kim, J. T., ... & Evers, M. (2018). Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget, 9(37), 24787.

Jung, M. Y., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., ... & Leof, E. B. (2018). Fatty acid synthase is required for profibrotic TGF-β signaling. The FASEB Journal, 32(7), 3803.

Carroll, R. G., Zasłona, Z., Galván-Peña, S., Koppe, E. L., Sévin, D. C., Angiari, S., ... & O’Neill, L. A. (2018). An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry, 293(15), 5509-5521.

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For research use only. Not intended for any clinical use.

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