FADD

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Fas Associated Via Death Domain

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841).

The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833).

Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833).

Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225).

Activation of cysteine-type endopeptidase activity Source: BHF-UCL
Apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: BHF-UCL
Behavioral response to cocaine Source: Ensembl
Cellular response to mechanical stimulus Source: UniProtKB
Death-inducing signaling complex assembly Source: UniProtKB
Defense response to virus Source: UniProtKB
Extrinsic apoptotic signaling pathway Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Kidney development Source: Ensembl
Lymph node development Source: UniProtKB
Motor neuron apoptotic process Source: Ensembl
Necroptotic signaling pathway Source: BHF-UCL
Negative regulation of activation-induced cell death of T cells Source: UniProtKB
Negative regulation of necroptotic process Source: Ensembl
Positive regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of adaptive immune response Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: BHF-UCL
Positive regulation of macrophage differentiation Source: UniProtKB
Positive regulation of proteolysis Source: BHF-UCL
Positive regulation of T cell mediated cytotoxicity Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: BHF-UCL
Positive regulation of type I interferon-mediated signaling pathway Source: UniProtKB
Response to morphine Source: Ensembl
Spleen development Source: UniProtKB
T cell differentiation in thymus Source: UniProtKB
T cell homeostasis Source: UniProtKB
Thymus development Source: UniProtKB
TRAIL-activated apoptotic signaling pathway Source: ParkinsonsUK-UCL

Cytosol; Ripoptosome; Nucleus; CD95 death-inducing signaling complex; Death-inducing signaling complex; Plasma membrane; Cell body; Cytoplasm; Membrane raft; Neuron projection

Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM):
A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).

(Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors.