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FADD Matched Antibody Pair (408) (APMAB-408LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-FADD polyclonal antibody, 100 ug
Detection Antibody
Anti-FADD Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Alternative Names
Fas Associated Via Death Domain; Fas-Associating Death Domain-Containing Protein; Growth-Inhibiting Gene 3 Protein; Fas-Associating Protein With Death Domain; Fas (TNFRSF6)-Associated Via Death Domain; Mediator Of Receptor-Induced Toxicity;
Entrez Gene ID
8772
UniProt ID
Q13158
More Infomation

He, X., Zhang, L., Hu, L., Liu, S., Xiong, A., Wang, J., ... & Li, G. (2021). PM2. 5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice. Journal of Asthma and Allergy, 14, 1411.

Xu, Z., Zheng, M., Liu, Y., Zhang, L., Zhang, X., & Bai, R. (2021). Roles of TNF receptor-associated and Fas-associated death domain proteins in the apoptosis of Eimeria tenella host cells. Veterinary Parasitology, 290, 109351.

Zhao, Y., Guo, M., Lv, Z., Zhang, W., Shao, Y., Zhao, X., & Li, C. (2020). Fas-associated death domain (FADD) in sea cucumber (Apostichopus japonicus): Molecular cloning, characterization and pro-apoptotic function analysis. Developmental & Comparative Immunology, 108, 103673.

Hollomon, M. G., Patterson, L., Santiago-O'Farrill, J., Kleinerman, E. S., & Gordon, N. (2020). Knock down of Fas-associated protein with death domain (FADD) sensitizes osteosarcoma to TNFα-induced cell death. Journal of Cancer, 11(7), 1657.

Koutsogiannaki, S., Hou, L., Babazada, H., Okuno, T., Blazon-Brown, N., Soriano, S. G., ... & Yuki, K. (2019). The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain–Fas-associated death domain interaction. The FASEB Journal, 33(11), 12668.

Mouasni, S., & Tourneur, L. (2018). FADD at the Crossroads between Cancer and Inflammation. Trends in immunology, 39(12), 1036-1053.

Muhammad, I. F., Borné, Y., Melander, O., Orho-Melander, M., Nilsson, J., Söderholm, M., & Engström, G. (2018). FADD (Fas-associated protein with death domain), caspase-3, and caspase-8 and incidence of ischemic stroke. Stroke, 49(9), 2224-2226.

Peng, M., Wang, Y., Qiang, L., Xu, Y., Li, C., Li, T., ... & Wang, J. (2018). Interleukin-35 inhibits TNF-α-induced osteoclastogenesis and promotes apoptosis via shifting the activation from tnf receptor-associated death domain (TRADD)–TRAF2 to TRADD–Fas-associated death domain by JAK1/STAT1. Frontiers in immunology, 9, 1417.

Hernández-Hernández, E., Miralles, A., Esteban, S., & García-Fuster, M. J. (2018). Repeated treatment with the α2-adrenoceptor agonist UK-14304 improves cognitive performance in middle-age rats: role of hippocampal Fas-associated death domain. Journal of Psychopharmacology, 32(2), 248-255.

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For research use only. Not intended for any clinical use.

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