EBF1

EBF1 (Early B-Cell Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include fetal erythroblastosis and hematologic cancer. Among its related pathways are Developmental Biology and Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and C2H2 zinc finger domain binding. An important paralog of this gene is EBF2.

EBF1

Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034).

Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity).

(Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461).

In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314).

Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus