CNTN4

CNTN4 (Contactin 4) is a Protein Coding gene. Diseases associated with CNTN4 include Spinocerebellar Ataxia Type 16 and Chromosome 3Pter-P25 Deletion Syndrome. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is CNTN3.

Contactin 4

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

Axonal fasciculation Source: UniProtKB
Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Negative regulation of neuron differentiation Source: UniProtKB
Nervous system development Source: UniProtKB
Neuron cell-cell adhesion Source: UniProtKB
Neuron projection development Source: UniProtKB
Regulation of synaptic plasticity Source: UniProtKB

Secreted; Cell membrane

A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.