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Rabbit Anti-CNTN4 Recombinant Antibody (BA0362) (CBMAB-0246CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0362
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide from residues in Human CNTN4
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Contactin 4
Introduction
This gene encodes a member of the contactin family of immunoglobulins. Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Entrez Gene ID
Human152330
Mouse269784
Rat116658
UniProt ID
HumanQ8IWV2
MouseQ69Z26
RatQ62845
Alternative Names
Contactin 4; Brain-Derived Immunoglobulin Superfamily Protein 2; BIG-2; Axonal-Associated Cell Adhesion Molecule; Neural Cell Adhesion Protein BIG-2; AXCAM
Function
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Biological Process
Axonal fasciculation Source: UniProtKB
Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Negative regulation of neuron differentiation Source: UniProtKB
Nervous system development Source: UniProtKB
Neuron cell-cell adhesion Source: UniProtKB
Neuron projection development Source: UniProtKB
Regulation of synaptic plasticity Source: UniProtKB
Cellular Location
Secreted; Cell membrane
Involvement in disease
A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
More Infomation

Zhao, R., Zhu, T., Liu, Q., Tian, Q., Wang, M., Chen, J., ... & Hu, Z. (2022). The autism risk gene CNTN4 modulates dendritic spine formation. Human molecular genetics, 31(2), 207-218.

Fernandez, T. (2021). CNTN4: Contactin 4. In Encyclopedia of Autism Spectrum Disorders (pp. 1011-1012). Cham: Springer International Publishing.

Oguro-Ando, A., Bamford, R. A., Sital, W., Sprengers, J. J., Zuko, A., Matser, J. M., ... & Kas, M. J. (2021). Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Translational psychiatry, 11(1), 1-15.

Zhang, S. Q., Fleischer, J., Al-Kateb, H., Mito, Y., Amarillo, I., & Shinawi, M. (2020). Intragenic CNTN4 copy number variants associated with a spectrum of neurobehavioral phenotypes. European Journal of Medical Genetics, 63(3), 103736.

Evenepoel, L., Van Nederveen, F. H., Oudijk, L., Papathomas, T. G., Restuccia, D. F., Belt, E. J., ... & Korpershoek, E. (2018). Expression of contactin 4 is associated with malignant behavior in pheochromocytomas and paragangliomas. The Journal of Clinical Endocrinology & Metabolism, 103(1), 46-55.

Heise, C., Preuss, J. M., Schroeder, J. C., Battaglia, C. R., Kolibius, J., Schmid, R., ... & Boeckers, T. M. (2018). Heterogeneity of cell surface glutamate and GABA receptor expression in shank and CNTN4 autism mouse models. Frontiers in molecular neuroscience, 11, 212.

Oguro-Ando, A., Zuko, A., Kleijer, K. T., & Burbach, J. P. H. (2017). A current view on contactin-4,-5, and-6: Implications in neurodevelopmental disorders. Molecular and Cellular Neuroscience, 81, 72-83.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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