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Mouse Anti-CNTN4 Recombinant Antibody (CBXC-1067) (CBMAB-C5515-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1067
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
NS0-derived recombinant human Contactin-4 isoform 1, Asp19-Gly1001, Accession # Q8IWV2
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Contactin 4
Introduction
CNTN4 (Contactin 4) is a Protein Coding gene. Diseases associated with CNTN4 include Spinocerebellar Ataxia Type 16 and Chromosome 3Pter-P25 Deletion Syndrome. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is CNTN3.
Entrez Gene ID
152330
UniProt ID
Q8IWV2
Alternative Names
Contactin 4; Brain-Derived Immunoglobulin Superfamily Protein 2; BIG-2; Axonal-Associated Cell Adhesion Molecule; Neural Cell Adhesion Protein BIG-2; Contactin-4; AXCAM;
Function
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Biological Process
Axonal fasciculation Source: UniProtKB
Axon guidance Source: GO_Central
Axonogenesis Source: UniProtKB
Brain development Source: UniProtKB
Dendrite self-avoidance Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
Negative regulation of neuron differentiation Source: UniProtKB
Nervous system development Source: UniProtKB
Neuron cell-cell adhesion Source: UniProtKB
Neuron projection development Source: UniProtKB
Regulation of synaptic plasticity Source: UniProtKB
Cellular Location
Secreted; Cell membrane
Involvement in disease
A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
More Infomation

Zhao, R., Zhu, T., Liu, Q., Tian, Q., Wang, M., Chen, J., ... & Hu, Z. (2022). The autism risk gene CNTN4 modulates dendritic spine formation. Human molecular genetics, 31(2), 207-218.

Fernandez, T. (2021). CNTN4: Contactin 4. In Encyclopedia of Autism Spectrum Disorders (pp. 1011-1012). Cham: Springer International Publishing.

Oguro-Ando, A., Bamford, R. A., Sital, W., Sprengers, J. J., Zuko, A., Matser, J. M., ... & Kas, M. J. (2021). Cntn4, a risk gene for neuropsychiatric disorders, modulates hippocampal synaptic plasticity and behavior. Translational psychiatry, 11(1), 1-15.

Zhang, S. Q., Fleischer, J., Al-Kateb, H., Mito, Y., Amarillo, I., & Shinawi, M. (2020). Intragenic CNTN4 copy number variants associated with a spectrum of neurobehavioral phenotypes. European Journal of Medical Genetics, 63(3), 103736.

Evenepoel, L., Van Nederveen, F. H., Oudijk, L., Papathomas, T. G., Restuccia, D. F., Belt, E. J., ... & Korpershoek, E. (2018). Expression of contactin 4 is associated with malignant behavior in pheochromocytomas and paragangliomas. The Journal of Clinical Endocrinology & Metabolism, 103(1), 46-55.

Heise, C., Preuss, J. M., Schroeder, J. C., Battaglia, C. R., Kolibius, J., Schmid, R., ... & Boeckers, T. M. (2018). Heterogeneity of cell surface glutamate and GABA receptor expression in shank and CNTN4 autism mouse models. Frontiers in molecular neuroscience, 11, 212.

Oguro-Ando, A., Zuko, A., Kleijer, K. T., & Burbach, J. P. H. (2017). A current view on contactin-4,-5, and-6: Implications in neurodevelopmental disorders. Molecular and Cellular Neuroscience, 81, 72-83.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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