CCNE1

Cyclin E1 is a key cell cycle regulator in normal cells. Many studies have found Cyclin E1 to be linked to disease progression and patient prognoses in several cancers including breast, bladder, colon, and ovarian carcinomas. Cyclin E1 is commonly uncontrolled in various cancers, and current research has found Cyclin E1 overexpression to be the cause for resistance against trastuzumab in HER2(+) breast cancer patients.

Cyclin E1

Essential for the control of the cell cycle at the G1/S (start) transition.

Cell division Source: UniProtKB-KW
DNA replication initiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: BHF-UCL
Homologous chromosome pairing at meiosis Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of mesenchymal stem cell proliferation Source: BHF-UCL
Protein phosphorylation Source: MGI
Regulation of cellular protein localization Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Telomere maintenance Source: Ensembl
Wnt signaling pathway Source: Ensembl

Nucleus

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.