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ACAN

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
Full Name
Aggrecan
Function
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Biological Process
Cell adhesion
Central nervous system development
Extracellular matrix organization
Keratan sulfate biosynthetic process
Keratan sulfate catabolic process
Proteolysis
Skeletal system development
Cellular Location
Extracellular matrix
Involvement in disease
Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts.
An autosomal dominant disease characterized by short stature, advanced bone maturation, early-onset osteoarthritis, and mild dysmorphic features consisting of midface hypoplasia, brachydactyly, broad great toes, and lumbar lordosis. Other features include intervertebral disk disease and osteochondritis dissecans. Osteochondritis dissecans is defined as a separation of cartilage and subchondral bone from the surrounding tissue.
PTM
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.

Anti-ACAN antibodies

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Target: ACAN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179208
Application*: WB, IH, IP
Target: ACAN
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat, Cat
Clone: V2-179203
Application*: WB, IH, IC, IF, IP
Target: ACAN
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: V2-179199
Application*: F, IH, WB, E, IP
Target: ACAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Cattle
Clone: V2-179196
Application*: WB, E, IH, P, C
Target: ACAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-179190
Application*: E, IF, WB
Target: ACAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179188
Application*: E, IH, WB
Target: ACAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: V2-5181
Application*: E, C, IP, P, WB
Target: ACAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Sheep, Rabbit, Horse, Guinea pig, Cattle, Cat, Dog, Pig
Clone: V2-12499
Application*: E, C, P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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