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APLN Matched Antibody Pair (086) (APMAB-086LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-APLN monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-APLN Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]
Alternative Names
Apelin; APJ Endogenous Ligand; APEL; Apelin, AGTRL1 Ligand; AGTRL1 Ligand; XNPEP2;
Entrez Gene ID
8862
UniProt ID
Q9ULZ1
More Infomation

Chen, L., Zhou, T., White, T., O'Brien, A., Chakraborty, S., Liangpunsakul, S., ... & Glaser, S. (2021). The Apelin–Apelin Receptor Axis Triggers Cholangiocyte Proliferation and Liver Fibrosis During Mouse Models of Cholestasis. Hepatology, 73(6), 2411-2428.

Suriyaprom, K., Pheungruang, B., Tungtrongchitr, R., & Orn-uma, Y. S. (2020). Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children. BMC pediatrics, 20(1), 1-10.

Wang, Y., Liu, W., Xiao, Y., Yuan, H., Wang, F., Jiang, P., & Luo, Z. (2020). Association of apelin and apelin receptor polymorphisms with the risk of comorbid depression and anxiety in coronary heart disease patients. Frontiers in genetics, 11, 893.

Griffiths, P. R., Lolait, S. J., Bijabhai, A., O’Carroll-Lolait, A., Paton, J. F., & O’Carroll, A. M. (2020). Increased apelin receptor gene expression in the subfornical organ of spontaneously hypertensive rats. PloS one, 15(4), e0231844.

Tolkach, Y., Ellinger, J., Kremer, A., Esser, L., Müller, S. C., Stephan, C., ... & Hauser, S. (2019). Apelin and apelin receptor expression in renal cell carcinoma. British journal of cancer, 120(6), 633-639.

Mercati, F., Scocco, P., Maranesi, M., Acuti, G., Petrucci, L., Cocci, P., ... & Dall’Aglio, C. (2019). Apelin system detection in the reproductive apparatus of ewes grazing on semi-natural pasture. Theriogenology, 139, 156-166.

Wang, W., Shen, M., Fischer, C., Basu, R., Hazra, S., Couvineau, P., ... & Oudit, G. Y. (2019). Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proceedings of the National Academy of Sciences, 116(26), 13006-13015.

Elsehmawy, A. A. E. W., El-Toukhy, S. E., Seliem, N. M. A., Moustafa, R. S., & Mohammed, D. S. (2019). Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus. Diabetes, metabolic syndrome and obesity: targets and therapy, 12, 383.

Wang, C., Liu, X., Kong, D., Qin, X., Li, Y., Teng, X., & Huang, X. (2017). Apelin as a novel drug for treating preeclampsia. Experimental and Therapeutic Medicine, 14(6), 5917-5923.

Roche, J., Ramé, C., Reverchon, M., Mellouk, N., Rak, A., Froment, P., & Dupont, J. (2017). Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells. Reproduction, 153(5), 589-603.

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For research use only. Not intended for any clinical use.

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