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Rabbit Anti-SSTR1 Monoclonal Antibody (UMB7) (CBMAB-1498-YC)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
UMB7
Antibody Isotype
IgG
Application
ICC, IF, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues in Human Somatostatin Receptor 1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
somatostatin receptor 1
Introduction
SSTR1 is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. SSTR1 has greater affinity for somatostatin-14 than -28.
Entrez Gene ID
6751
UniProt ID
P30872
Alternative Names
SS1R; SS1-R; SRIF-2; SS-1-R
Function
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.
Biological Process
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process cerebellum developmentIEA:Ensembl
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process glutamate receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to starvationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-56
Helical: 57-84
Cytoplasmic: 85-94
Helical: 95-120
Extracellular: 121-131
Helical: 132-153
Cytoplasmic: 154-175
Helical: 176-196
Extracellular: 197-219
Helical: 220-244
Cytoplasmic: 245-270
Helical: 271-296
Extracellular: 297-303
Helical: 304-327
Cytoplasmic: 328-391
More Infomation
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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